Pharmacokinetics of inhaled anaesthetics in a clinical setting: description of a novel method based on routine monitoring data.
نویسندگان
چکیده
Pharmacokinetic parameters of inhaled anaesthetics have previously been assessed experimentally in healthy volunteers. In contrast, we developed a method to estimate pharmacokinetic parameters under clinical conditions. We obtained data from the continuous routine monitoring of fractional concentration and ventilation during anaesthesia with desflurane, isoflurane and sevoflurane. By simulation studies, we assessed the effects of several sources of variation, including the noise of measurement, the second gas effect and rounding errors or a limited number of displayed digits. Stable fits to a two-compartment model were obtained for both real and simulated data sets in all cases. The most stable parameter was the intercompartmental clearance, and the most sensitive parameter was the volume of distribution. The bias in pharmacokinetic parameters caused by adding errors to measured concentrations was similar for the different compounds. We conclude that the model allows the estimation of an alternative set of pharmacokinetic parameters that can reliably describe the behaviour of volatile anaesthetics under clinical conditions, and allow comparison between agents.
منابع مشابه
A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
متن کاملPharmacokinetics of inhaled anaesthetics in a clinical setting: comparison of desflurane, isoflurane and sevoflurane.
The pharmacokinetic characteristics of desflurane, isoflurane and sevoflurane (16 patients for each anaesthetic) were estimated from measurements of inspired and end-expired agent concentrations and ventilation, obtained during routine anaesthesia in patients undergoing maxillofacial surgery (mean age 38 yr, duration of anaesthesia approximately 2 h). A two-compartment model described the data ...
متن کاملA case study for application of fuzzy inference and data mining in structural health monitoring
In this study, a system for monitoring the structural health of bridge deck and predicting various possible damages to this section was designed based on measuring the temperature and humidity with the use of wireless sensor networks, and then it was implemented and investigated. A scaled model of a conventional medium sized bridge (length of 50 meters, height of 10 meters, and with 2 piers) wa...
متن کاملNursing students experiences toward evidence-based learning in clinical setting: A qualitative study
Introduction: Evidence-based learning is an effective educational strategy. Assessment of nursing student’s viewpoints about this new method can increase its application. This research was conducted to find out student’s experiences toward evidence-based learning in clinical setting. Methods: This qualitative study was performed by grounded theory method in 2010. Eighteen nursing students were...
متن کاملA PCA/ICA based Fetal ECG Extraction from Mother Abdominal Recordings by Means of a Novel Data-driven Approach to Fetal ECG Quality Assessment
Background: Fetal electrocardiography is a developing field that provides valuable information on the fetal health during pregnancy. By early diagnosis and treatment of fetal heart problems, more survival chance is given to the infant.Objective: Here, we extract fetal ECG from maternal abdominal recordings and detect R-peaks in order to recognize fetal heart rate. On the next step, we find a be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British journal of anaesthesia
دوره 84 4 شماره
صفحات -
تاریخ انتشار 2000